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KMID : 1146920180480040443
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Journal of Pharmaceutical Investigation
2018 Volume.48 No. 4 p.443 ~ p.450
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Evaluation of antimicrobial effect of DA-5502 in gingivitis and periodontal diseases
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Ruttala Hima Bindu
Kang Min-Kyung
Park Hyoung-Geun
Yong Chul-Soon
Jun Joon-Ho
Kim Jong-Oh
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Abstract
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The aim of present study was to examine the bactericidal and antimicrobial activity of novel DA-5502 in gingivitis and periodontal diseases. The in vitro antimicrobial activity of DA-5502 was investigated against two strains Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans by biofilm and planktonic method. DA-5502 effectively inhibited both the biofilm formation and oral bacteria in planktonic state for both P. gingivalis and A. actinomycetemcomitans strains, which results in reduction of plaque and gum inflammation. The in vitro results provide scientific evidence that our novel DA-5502 liquid dentifrice formulation composed of cetylpyridinium chloride, dipotassium glycyrrhizinate, and panthenol as main active pharmaceutical ingredients, has effective adsorption capacity with excellent antimicrobial, antigingivitis, and antiplaque activity to treat periodontal diseases.
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KEYWORD
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DA-5502, Liquid dentifrice, Dipotassium glycyrrhizinate, Gingivitis, Periodontal diseases
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